Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
نویسندگان
چکیده
منابع مشابه
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood-brain barrier (BBB) and effectively reduce brain amyloid β levels. We found that optimizing anti-TfR affinity improves brain exposure and BACE1 inhibition. Here we probe the...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2014
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20131660